But you’ll have the option to repeat them if you want as they’ll reset in each new playthrough. However, if you start over in a new game plus save after finishing the story once, the progress will remain for the requests’ corresponding challenge.
There is a certain number for each region in the game - the Village, Castle, and Island areas - and you’ll need to complete them before moving on to the next region. There is a total of 19 requests to take care of throughout the course of the story. How requests work in Resident Evil 4 remake
